The team of researchers hope to provide proof of concept for large genome synthesis by creating a fully synthetic human chromosome, which makes up approximately 2% of our total DNA. Initially, the team hope to establish methods where small changes are made to the sequence of a chromosome with minimal onward effect on the proteins that it produces.
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Over the next five years, the team will undertake a transdisciplinary and transcultural investigation into the socio-ethical, economic, and policy implications of synthesising human genomes. The project places particular emphasis on fostering inclusivity within and across nation-states, while engaging emerging public–private partnerships and new interest groups.
link to project https://www3.mrc-lmb.cam.ac.uk/sites/synhg/
and to Wellcome Trust message https://wellcome.org/news/new-project-pioneer-principles-human-genome-synthesis
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