I meant the other way around, my bad. The DMG style GameBoy carts could probably be played in the clone console this cart came with. From the appearance of another comment, it likely would have been a keyboard with cart slots big enough to accommodate genuine DMG style cartridges on it.
Physical console design? Atari 2600. The black slots and wood grain front with the sleek angular design is still peak console styling IMO.
User interface design? Xbox 360 Blades. Hands down. Easy to navigate, easy to understand, and good potential for minimal advertising abuse.