Oh boy it’s my time to shine!

I’m working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about… So this is what his lab is doing.

Two important disclaimers:

• Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don’t behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven’t even made it into phase 1… so I wouldn’t be too optimistic about them.
• The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I’d be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

The link between cell senescence and aging is something actively being studied tho.

And, if anyone is curious about this topic: I’m also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.

mailbox.org and skiff are „too expensive“ with 3€/month.

Ah… I do use mailbox.org and I’ve self-hosted with docker-mailserver before.

I agree, selfhosting mail is a really big pain, and at least where I live most ISPs don’t open the ports necessary for mailservers, so I had to spin up my own server & it was more expensive than just using a mail provider. Could potentially be the cheapest option if I could host it from home & just use a RasPi or something

I’m happy with mailbox.org; the Standard Tier price is 2.50 Euro/mo if paid in full if that helps. Probably not the cheapest option especially since it’s not unlimited, but they do allow domain matches at Standard tier or above, and there are other goodies like calendar/video conferencing/cloud storage & stuff.

Thanks! Wowzers I’ve never heard of Nature Food, didn’t realize this journal had such a high impact factor. A few things of interest to me from the article…

• Vegans are one standard deviation younger than heavy-meat-eaters and eat fewer calories… although they should have adjusted for the difference
• This didn’t show on the fancy Monte Carlo simulation they did, but vegans emit much, MUCH less methane than any other group
• Literally any group is significantly better than heavy meat-eaters, especially low meat-eaters or below

The questionnaire they used to determine categories:

• Do you eat any meat (including bacon, ham, poultry, game, meat pies, sausages)? (Vegans, vegetarians and fish-eaters respond ‘No’.)
• Do you eat any fish? (Vegans and vegetarians respond ‘No’.)
• Do you eat any eggs (including eggs in cakes or other baked goods)? (Vegans respond ‘No’.)
• Do you eat any dairy products (including milk, cheese, butter, yoghurt)? (Vegans respond ‘No’.)
  And meat-eaters are divided by grams of meat eaten per day: <50 g/d, 50-100 g/d, >100 g/d. Apparently one patty from McDonald’s (Big Mac has two) is like 45 grams of beef so…

I mean the conclusions aren’t anything surprising, cows are literally one of the major sources of environmental damage… But it does provide some way moving forward I suppose. I suspect banning steakhouses would have a much better impact than forcing everyone to be vegan lol

So having all the mods quit is actually a viable way to protest? (writes down notes)