Prior to 1800, an estimated 50,000 grizzly bears were distributed in one large contiguous area throughout all or portions of 18 western States, including Washington, Oregon, California, Idaho, Montana, Wyoming, Nevada, Colorado, Utah, New Mexico, Arizona, North Dakota, South Dakota, Minnesota, Nebraska, Kansas, Oklahoma and Texas.
Grizzly bears were reduced to close to 2% of their former range in the 48 contiguous states by the 1930s, with a corresponding decrease in population, approximately 125 years after first contact with European settlers.
The kill-to-death ratio is pretty favorable to humans.
This list is probably not a complete accounting of all incidents, but it dates back to the 1780s, and has 88 cases where a brown bear killed a human.
https://en.wikipedia.org/wiki/List_of_fatal_bear_attacks_in_North_America
Going the other direction:
https://www.fws.gov/species/grizzly-bear-ursus-arctos-horribilis
The kill-to-death ratio is pretty favorable to humans.